Modulus Microplate Multimode Reader

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Modulus Microplate Multimode Reader

"I just received our brand new Modulus. It only takes 15 minutes to set it up and it is extremely easy for us to use. I invited everyone in the company to see and use the Modulus. Turner’s engineering is something I can expect the best and I am always impressed with. I have evaluated most of your luminometers and I have now two (20/20n and Modulus) in my lab."

E-mail from customer who purchased the Modulus Microplate instrument


"I received the Modulus. It is so easy to set up and program the instrument, I did it in 15 minutes. My interns tested absorbance module at 450 nm and it read wonderful. All the parts are working well. We will evaluate luminometer and absorbance modules in the next two weeks. I was very impressed with the system."


E-mail from customer evaluating the Modulus Microplate Multimode Reader.


Modulus™ Microplate Multimode Reader


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  • Ease of Use
  • Value
  • Flexibility

Turner BioSystems has reinvented the multimode reader. The Modulus™ Microplate Multimode Reader is skillfully designed for today's life science laboratory, incorporating state-of-the-art optics, instrumentation, data handling, and performance with flexible purchasing options.

To read Frequently Asked Questions on this product, click here.

Configurable and Scalable Detection Modes
Configure the Modulus™ Microlate Reader as a single or multimode detection system. It can be purchased as a stand alone fluorometer, luminometer, photometer, or as a multimode reader. The detection modules are modular and independent. Choose and configure however you want to fit your needs. Add any detection modules later as your needs expand.

Superior Performance
A wide dynamic range of sensitivity enables this instrument to read both the highest and lowest sample signal intensities in one run, without dilution.

Ease of Use
A built-in computer makes set up simple. Intuitive touch-screen controls, color graphics, Windows-based software, and protocol wizards are easy to use. Control of the instrument via an external PC is possible, but not required.

Easy Data Transfer
Using the included USB port and flash drive, transfer data directly from the instrument to an alternate computer (PC or Mac) for maximum convenience when analyzing results. Data transfers free up the instrument for the next user and improve lab productivity by reducing wait time.

Flexible Customization Options
Purchase the detection modules fitting the current needs of your lab and acquire additional modules as required in the future. The luminescence module is installed at one of Turner BioSystems' global service centers. Other modules and injectors are installed in your lab.

Value
Combining modular flexibility with a simplified optical design improves instrument performance, as well as reducing the cost of maintenance and unnecessary system acquisitions.

Modulus Microplate

Superior Performance

The Modulus™ Microplate Multimode Reader uses a dedicated detector system for each measurement mode, whereas most other multimode instruments share one detector for several measurement modes. Our unique dedicated detector approach produces uncompromised sensitivity and a wider dynamic range in comparison to other multimode readers. The Modulus™ Microplate Multimode Reader yields the superior performance expected from single-mode instruments.

Ease of Use

  • Built-in PC
    The Modulus™ Microplate Multimode Reader includes a built-in PC, Windows CE™, and touch-screen controls. Connectivity and compatibility issues are eliminated and less bench space is needed. An external PC is not required, however, the instrument can be connected to and operated from an external PC by purchasing the optional External PC Connect Kit.
  • Easy Data Transfer
    Results are stored in the instrument's memory and then are easily downloaded onto the included USB flash drive. Transfer the USB flash drive to a Mac or PC for data review and analysis. If desired, use the optional External PC Connect Kit to automatically download data to an external PC for networking or other purposes.
  • Touch-Screen Navigation
    The large, high-resolution touch screen, combined with Windows CE™, makes the Modulus™ Microplate Multimode Reader easy to navigate. The intuitive user interface provides instrument control, protocol management, and data management. Protocol and fluidics wizards guide users through setup and operation. Context-sensitive Help screens provide detailed explanations of key functions.
  • Immediate Results
    The dynamic features of the Modulus™ Microplate Multimode Reader make it easy to immediately start reading assays and compiling results. Spend less time on set up and more time on science.

Value

The unique features of the Modulus™ Microplate Multimode Reader reduce costs in several ways. First, purchase only what is needed now and add to the system in the future. Most instrument detection modules and accessories can be purchased and installed after the initial instrument purchase. Second, reduce system downtime as repairs may be performed on individual modules instead of the whole system. Finally, boost lab productivity by saving time spent on training lab staff because the system is so easy to use.

Flexibility

Scalable Detection Modules
The Modulus™ Microplate Multimode Reader is a scalable system designed for measuring fluorescence, luminescence, and absorbance. Using a dedicated detector approach, each module has an independent optical system. The instrument can be purchased as a single-mode dedicated fluorometer, luminometer, or photometer or as a multimode reader with up to three detection modules installed. Fluorescence and absorbance modules can be installed by the user after initial purchase. This revolutionary modular approach allows adaptable system expansion as needs change in the lab.

Modulus Microplate Multimode Reader Injector System


Injector Systems
Optional systems for single or dual injectors are available and can be added at any time. Each injector has a volume range of 25 - 200 l in 5-l increments. Installed injector systems are automatically recognized by the instrument and controlled using the touch screen and fluidics wizard. Prime and Flush commands provide easy maintenance and a Reverse Purge command saves reagents. These injector systems are designed for easy and economical performance of dual reporter and other flash assay protocols.

Curve-Fitting Software
Optional Curve-Fitting Data Analysis Software easily enables concentration calculation, graphing, and printing. Eight different curve-fitting methods are available: linear fit, quadratic fit, cubic fit, two-parameter fit, four-parameter with linear x-axis fit, four-parameter with log two-axis fit, point-to-point, and cubic spline. This software is compatible with the Windows XP operating system for PC computers.


Fluorescence

The Modulus™ Microplate Multimode Reader with the Fluorescence Module installed stands alone as a high-performance fluorometer. The system can be alternatively configured as a multimode reader for measuring fluorescence, luminescence, and absorbance by purchasing and installing the luminescence and absorbance modules.

Modulus Microplate Fluorescence ModuleModulus Microplate Multimode Reader Fluorescence Optical Kits

Superior performance is achieved by using a dedicated fluorescence detector instead of sharing the detector with other measurement modules. Optimum sensitivity is enabled with modern solid-state optics rather than traditional lamps and detectors. Each Fluorescence Optical Kit employs a powerful LED to excite samples with energy at the optimum wavelength for the selected application. This results in superior sensitivity, specificity, and flexibility.

The Modulus Microplate Fluorometer has a detection limit of 0.5 fmol/200 ul of fluorescein

The Modulus™ Microplate Multimode Reader Fluorescence Module features a dedicated optical design to read epifluorescence samples from above. A detection head and four Fluorescence Optical Kits are included to measure the most popular fluorophors. Optical kits can be easily exchanged in seconds. Instrument software ensures that the installed optical kit matches the selected application protocol.

Protocols for nucleic acids and proteins such as PicoGreen®, RiboGreen®, and Quant-iT™ assays are preprogrammed into the instrument for convenience. Cell-based fluorescence assays and gene expression assays using various fluorescent proteins can also be measured.

Optical Kit
Excitation Wavelength
Emission Wavelength
Typical Fluorophors
UV
365 nm
410 - 460 nm
Hoechst dye, 4-MU
Blue
490 nm
510 - 570 nm
PicoGreen®, RiboGreen®,
Fluorescein, Quant-iT™ Protein,
Quant-iT™ dsDNA, EGFP, or rAcGFP
Green
525 nm
580 - 640 nm
Rhodamine, Cy®3
Red
625 nm
660 - 720 nm
Cy®5, Quant-iT™ RNA

 


Luminescence

The Modulus™ Microplate Multimode Reader with the Luminescence UHS Module installed stands alone as a high-performance luminometer. The system can be alternatively configured as a multimode reader for measuring luminescence, fluorescence, and absorbance by purchasing and installing the fluorescence and absorbance modules.

Modulus Microplate Multimode Reader Luminescence Module

Superior performance is achieved by using a dedicated luminescence detector instead of sharing the detector with other measurement modules. Optimum sensitivity is achieved with low-noise circuitry, unique optical design, and a premium photon-counting photomultiplier tube (PMT). Minimal crosstalk is realized with our proprietary dual-masking systems where one mask covers the well while another covers the detector.
DLR Ready Instrument

The Modulus Microplate Luminometer  has a detection limit of 3 x 10-21 moles of luciferase and >8 logs of linear dynamic range

Protocols for popular assays like Promega’s Dual-LuciferaseTM are preprogrammed into the instrument for convenience. These protocol wizards in combination with high performance and ease of use form an exceptional luminometer.

Luminescence Light Plate

The optional Luminescence Light Plate provides an external control to ensure the luminometer is functioning properly. Some labs require this additional verification procedure. Reading the light plate before taking measurements is a quick and easy way to ensure quality control over linearity and consistency of readings.

Luminescence Light Plate


Superior Performance

The Modulus™ Microplate Absorbance Reader provides measurements that are highly sensitive and cover a wide dynamic range. Superior performance is achieved by use of a large-area photodiode. The instrument can detect linear dynamic ranges from 0 – 4.0 OD, allowing undiluted samples of both low and high OD to be read simultaneously in the same microplate.

To read our Frequently Asked Questions on this product, click here.

Figure 1
OD range using Nigrosin dilutions. When using the Modulus™ Microplate Absorbance Module OD values as low as 0.06 can be measured.

Customizable

The Modulus™ Microplate Absorbance Reader has a six-position filter wheel. This filter wheel holds four factory-installed filters plus two additional filter positions are open for custom filters. The four installed filters have wavelengths of 450, 560, 600, and 750 nm with 10 nm bandwidth. The two open positions on the filter wheel can accommodate any 0.5-cm filter in the spectral range of 400 – 800 nm. Selecting the optimal filter for your application is simple by using the color touch-screen of the ModulusTM Microplate Absorbance Reader graphical user interface.

For ratiometric assays, two wavelengths can be selected for each absorbance reading. OD values for each wavelength or a ratio of the two appear on the easy-to-read display screen. Easily measure microplates of ELISA assays as ratiometric assays where the readings include adjustment to account for optical imperfections.

Figure 2
Customizable filter paddles can easily be inserted into the rotating filter wheel attached to the absorbance head. Note: The filter wheel is not removable. Drawing is for demonstration only.

 

Assays
Wavelength
ELISA, QuantiCleave™ Protease Assay
450
BCA™ Protein Assays
560
Bradford Protein Assays, Coomassie Blue Protein Assays, PeroXOquant™ Quantiative Peroxide Assay
600
Lowry Protein Assay
750

Table 1
Filter wavelengths for various assays.

Figure 3
Drawing of absorbance head and detection path.

Ease of Use

• Built-in PC
The Modulus™ Microplate Absorbance Reader includes a built-in PC, Windows CE™, and touch-screen controls. Connectivity and compatibility issues are eliminated and less bench space is needed. An external PC is not required, however, the instrument can be connected to and operated from an external PC by purchasing the optional External PC Connect Kit.

• Easy Data Transfer
Results are stored in the instrument’s memory and then are easily downloaded onto the included USB flash drive. Transfer the USB flash drive to a Mac or PC for data review and analysis. If desired, use the optional External PC Connect Kit to automatically download data to an external PC for networking or other purposes.

• Touch-Screen Navigation
The large, high-resolution touch screen, combined with Windows CE™, makes the Modulus™ Microplate Absorbance Reader easy to navigate. The intuitive user interface provides instrument control, protocol management, and data management. Protocol and fluidics wizards guide users through setup and operation. Context-sensitive Help screens provide detailed explanations of key functions.

• Immediate Results
The dynamic features of the Modulus™ Microplate Absorbance Reader make it easy to immediately start reading assays and compiling results. Spend less time on set up and more time on science.

Scalable Detection Modules

The Modulus™ Microplate Absorbance Reader stands alone as a high-performance photometer. The system can be alternatively configured as a multimode reader for measuring absorbance and fluorescence by purchasing and installing the fluorescence module. Installation of the fluorescence module is performed one time and takes less than five minutes. This revolutionary modular approach allows adaptable system expansion as needs change in the lab.

Value

The unique features of the Modulus™ Microplate Absorbance Reader reduce costs in several ways. First, purchase only what is needed now and add to the system in the future. The fluorescence detection module and accessories can be purchased and installed after the initial instrument purchase. Second, reduce system downtime as repairs may be performed on individual modules instead of the whole system. Finally, boost lab productivity by saving time spent on training lab staff because the system is so easy to use.


Specifications

Instrument Specifications

Detection Modes: luminescence, fluorescence, and absorbance
Sample Format: 96-well microtiter plate
Read Format: 1 - 96 samples in 96-well microplate
Read Type: Single Read or Repeat Reads (2 - 99 reads; 1 - 120 minute intervals)
Integrated PC Operating System: Windows CE
User Interface: 6.6" VGA color LCD display with touch screen, TFT
Data Output: USB flash drive, PC or Mac compatible csv file format
External PC Requirements (optional): Windows XP or higher operating system
Dimensions: 53 cm D x 44 cm W x 31 cm H
(21" D x 17.3" W x 12.2" H)
Weight: ~16 kg (~35 lbs)
Power Source: 100 - 240 VAC, 50/60 Hz
Operating Temperature: 15 - 30°C (60 - 85°F)
Operating Humidity: 5 - 75% noncondensing
Warranty: 1 year parts & labor
Regulatory: CE, for research use only

Optional Injector System Specifications

Number of Injectors: single or dual injectors
Dispense Volume Range: 25 - 200 µl in 5 µl increments
Waste Tray Volume: ~50 ml

Luminescence Specifications

Detector: head-on photomultiplier tube (PMT) for photon counting
Wavelengths: 350 - 650 nm
Kinetic Read: 0.1 - 60 sec in steps of 0.1 sec; 2 - 250 data points
Detection Limit: 3 x 10-21 moles of luciferase
Linear Dynamic Range: >8 decades
Cross-Talk: 5 x 10-6 using Costar #3789 plates

Fluorescence Specifications

Light Source: wavelength-matched LED
Detector: PIN-photodiode
Read Position: top reading
Wavelength Selection: snap-in Fluorescence Optical Kits
Wavelengths: UV (Ex: 365 nm, Em: 410 - 460 nm), Blue (Ex: 490 nm, Em: 510 - 570 nm), Green (Ex: 525 nm, Em: 580 - 640 nm), Red (Ex: 625 nm,
Em: 660 - 720 nm)
Detection Limit: 0.5 fmol/200 µl or 1 ppt of
fluorescein in 96-well plate
Linear Dynamic Range: 6 decades, assay
dependent

Absorbance Specifications

Light Source: LED
Detector: Large-area Photodiode
Spectral Range: 400 - 800 nm
Filter Wheel Capacity: Up to six filters (four filters installed, two filter holders for customization).
Wavelengths: 450, 560, 600, 750 nm
Filter Bandwidth: 10 nm
Photometric Measuring Range: 0 - 5.0 OD
Linear Dynamic Range: 0 - 4 OD @ 450 - 700 nm
OD Accuracy: 0.01 OD + 3% < 2.5 OD
OD Precision: < 0.2% @ 0-4 OD
Stray Light: 0.002% @ 560 nm with clear bottom, black-wall plates
Instrument MDL: 5 m OD @ 560 nm


For research use only. Not for use in diagnostic procedures.
Modulus is a trademark of Turner BioSystems, Inc. All other trademarks are the sole property of their respective owners.


Terms of iPod Promotion:
Promotion is valid until Sept 1, 2008 and only valid in the U.S. and Canada. Promotion applies only to instruments purchased directly from Turner BioSystems. Void where prohibited. Subject to change without notice. Not to be combined with any other offers. Modulus Microplate Multimode Reader is a registered trademark of Turner BioSystems. iPod is a registered trademark of Apple Inc. [Request a Quotation]

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Turner BioSystems, Inc.
Turner BioSystems, Inc.

645 N Mary Avenue
Sunnyvale CA 94085
Phone: 408.636.2400 - Toll Free: 888.636.2401 - Fax: 408.737.7919